Regulation of Sodium and Potassium Transport in Phytohemagglutinin-Stimulated Human Blood Lymphocytes

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Regulation of sodium and potassium transport in phytohemagglutinin-stimulated human blood lymphocytes.

Phytohemagglutinin (PHA) or concanavalin A treatment of lymphocytes causes an increase in membrane permeability so that the leak rates of Na and K increase 1.5- to 2-fold. Active Na and K transport increase proportionately in response to the increased membrane permeability. We have examined the role of lymphocyte Na concentration in sustaining the increased Na and K transport observed after PHA...

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Potasssium transport in human blood lymphocytes treated with phytohemagglutinin.

We have confirmed that phytohemagglutinin (PHA) rapidly enhances the uptake of potassium (K+) by human blood lymphocytes. PHA, however, did not produce an increase in lymphocyte K+ concentration. The apparent steady-state of cell K+ concentration despite the marked increase in uptake of 42K+ could be explained by either an increase in K+-K+ exchange or an increase in concentrative (active) K+ a...

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Replication of poliovirus in phytohemagglutinin-stimulated human lymphocytes.

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1979

ISSN: 0021-9738

DOI: 10.1172/jci109531